Lay Explanations:
Medicine For You
Information from the National Institute of Health that explains pharmacogenetics in layman’s terms.
Pharmacogenomics
As explained by the American Medical Association.
Preventable Adverse Drug Reactions: A Focus on Drug Interactions
A learning module developed by the Center for Education and Research on Therapeutics (CERT) in collaboration with the Center for Drug Evaluation and Research at the Food and Drug Administration.
Other Resources:
Genomic Medicine – A Primer, New England Journal of Medicine
An overview by Guttmacher and Collins
Cytochrome P450 Table of Drugs with links to PubMed Articles
A list of some of the drugs affected by genetic variations and they’re respective genes
Cytochrome P450 Enzymes and Psychopharmacology
By Sheldon H. Preskorn, M.D. and Anne T. Harvey, Ph.D.
PharmGKB
The Pharmacogenetics and Pharmacogenomics Knowledge Base
Scientific Papers:
How common are drug and gene interactions? Prevalence in a sample of 1143 patients with CYP2C9, CYP2C19 and CYP2D6 genotyping.
Verbeurgt P, Mamiya T, Oesterheld J. How common are drug and gene interactions? Prevalence in a sample of 1143 patients with CYP2C9, CYP2C19 and CYP2D6 genotyping. Pharmacogenomics. 2014;15(5):655-65. PubMed PMID: 24798722.
Clinical Guidelines for Psychiatrists for the Use of Pharmacogenetic Testing for CYP450 2D6 and CYP450 2C19
de Leon J, Armstrong SC, Cozza KL. Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19. Psychosomatics. 2006 Jan-Feb;47(1):75-85.
Drug-metabolizing enzymes: Evidence for clinical utility of pharmacogenetic tests
Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM et al. Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests. Clin Pharmacol Ther. 2005 Dec;78(6):559-81.
Cancer pharmacogenomics: current and future applications
Watters JW, McLeod HL. Cancer pharmacogenomics: current and future applications. Biochim Biophys Acta. 2003 Mar 17;1603(2):99-111.
Pharmacogenomics study of statin therapy and cholesterol reduction
Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP Jr, Ridker PM. Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004 Jun 16;291(23):2821-7.
Role of pharmacogenomics in individualising treatment with SSRIs
Mancama D, Kerwin RW. Role of pharmacogenomics in individualising treatments with SSRIs. CNS Drugs. 2003;17(3):143-51.
Cardiovascular pharmacogenomics: current status, future prospects
Anderson JL, Carlquist JF, Horne BD, Muhlestein JB. Cardiovascular pharmacogenomics: current status, future prospects. J Cardiovasc Pharmacol Ther. 2003 Mar;8(1):71-83.
Pharmacogenomics — Drug disposition, drug targets, and side effects
Evans WE, McLeod HL. Pharmacogenomics — drug disposition, drug targets, and side effects. N Engl J Med. 2003 Feb 6;348(6):538-49.
Inheritance and Drug Response, New England Journal of Medicine
Weinshilboum. Inheritance and Drug Response. N Engl J Med. 2003;348:529-537.
Genes and Drug Response, New England Journal of Medicine
Caraco Y. Genes and the Response to Drugs. N Engl J Med. 2004;351(27):2867-2869.
Pharmacogenomics – Drug Disposition, Drug Targets, and Side Effects, New England Journal of Medicine
Evans WE, McLeod HL. Pharmacogenomics – Drug Disposition, Drug Targets, and Side Effects. N Engl J Med. 2003;348:538-549.
Application of Pharmacogenomics in Clinical Pharmacology, Toxicology Mechanisms and Methods
Huang S, Goodsaid F, Rahman A, Frueh F, Lesko LJ. Application of Pharmacogenomic in Clinical Pharmacology. Toxicology Mechanisms and Methods. 2006;16:89-99.
